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Pharmaceuticals

 
 
Pharmaceuticals refer to the production of medicines for the prevention, treatment or diagnosis of diseases using biological, chemical or traditional Chinese medicine theories and methods.
 
They are mainly divided into three categories: biopharmaceuticals, chemical pharmaceuticals and traditional Chinese medicine pharmaceuticals. Each category serves different medical needs according to its raw materials and preparation methods.
Application Introduction
Application Challenges
Solutions
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Applications of Microscopic Imaging in Pharmaceuticals

 
 
Three main types of microscopic imaging techniques are commonly used in pharmaceutical engineering: brightfield observation, polarized observation, and phase contrast observation.
 

Brightfield observation combined with simple polarized observation is an effective method for identifying powder components of traditional Chinese medicines.

 

Professional polarized observation can be used to identify the crystal forms of pharmaceutical ingredients. When combined with a constant-temperature & high-temperature heating stage, it enables the study of conditions for crystal form changes, which has a significant impact on the efficacy of chemical drugs.

 
Phase contrast observation is mainly used for cell culture observation and vaccine development in various biopharmaceutical applications.
 
In addition, fluorescence imaging is applied in some pharmacodynamic test studies, while Raman hyperspectral imaging is used in certain pharmaceutical process research.

Challenges of Microscopic Imaging in Pharmaceuticals

 
Adapting to diverse pharmaceutical technologies requires a balance among cost, performance, and complete supporting solutions.
 
For traditional Chinese medicine identification, budgets are often insufficient for professional polarized microscopes, making biological microscopes supporting simple polarized observation a better choice.
 
Professional polarization requires matching with a reliable high-temperature heating stage.
 
Phase contrast observation for cell culture faces challenges in cleanroom space and contamination prevention.
 
In addition, fluorescence imaging encounters difficulties in fluorescence excitation efficiency and camera sensitivity.

Solutions for Microscopic Imaging in Pharmaceuticals

●For large-scale biopharmaceutical applications, the MI52-CF Cell Factory Microscope and MCF400 Cell Factory Imager are recommended.
The MI52-CF features an adjustable condenser height, enabling observation of large-scale culture vessels such as cell factories up to 10 layers.
The MCF400 is specifically designed for imaging cell factories up to 40 layers, allowing observation of the edge conditions of each layer.
● For general biopharmaceutical applications, the inverted (fluorescence) microscope MI52-N (MF52-N) and live cell imagers MCS11/MCS21 are recommended.
MI52-N/MF52-N supports routine phase contrast observation and fluorescence transfection observation.
MCS11/MCS21 can be placed inside incubators for remote management and long-term imaging monitoring of culture progress, greatly improving work efficiency.
● For chemical pharmaceutical applications, the professional polarizing microscope MP41 with the high-temperature heating stage K3000 is provided to meet the needs of crystal form observation and research.
● For traditional Chinese medicine identification, the biological polarizing microscope ML31-P with a microscope camera is recommended, offering simple polarized observation and significant cost advantages.
● For drug efficacy tracking, the inverted fluorescence microscope MZX81/100 with a high-sensitivity camera is recommended.

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