Cholera, caused by Vibrio cholerae, has long been a major challenge in the global public health sector. Currently, oral rehydration, though an important treatment for cholera, cannot inhibit bacterial virulence and has limited efficacy in specific populations.
A research team led by Liu Bin from Nankai University and Tang Guosheng from Guangzhou Medical University published a paper titled “Vibrio cholerae virulence is blocked by chitosan oligosaccharide-mediated inhibition of ChsR activity” in the top international journal Nature Microbiology.
This study, which focuses on the virulence regulatory mechanism of Vibrio cholerae, has made significant progress. And the acquisition of some key experimental data would not have been possible without the excellent performance of MSHOT’s inverted fluorescence microscope MF53-N.
MF53-N Microscope: The “High-Definition Eye” Behind Scientific Research
The research-grade inverted fluorescence microscope MF53-N
- Equipped with a 6-hole turret fluorescence module and an ultra-long lifespan LED fluorescence light source.
- Can be expanded and upgraded to enable various observation methods.
- The high numerical aperture semi-apochromatic objectives deliver clear imaging
- Can be upgraded with a high-precision XYZ three-axis motorized stage.
LED Light Source MG-120:
- A high-brightness LED fluorescent microscope light source with an ultra-long lifespan of 20,000 hours.
- 4channels of high-power LED lamp beads, each group of which can be independently controlled for on/off and brightness adjustment via touch screen.
- Ready to use instantly, with immediate on/off functionality. Its spectral coverage includes common fluorescent dyes such as DAPI, GFP, FITC, RFP, YFP, CY3, and CY5, and the wavelength bands can be customized.
- Becompatible with research-grade upright, inverted, and stereoscopic fluorescent microscopes of different brands.
Semi-apo fluorescent objectives:
- These high numerical aperture semi-apo fluorescent objectives boast high definition and excellent fluorescence transmittance.
- They produce sharp images under brightfield fluorescence, meeting the observation needs in various fluorescent fields.
Filters
- Customized filter sets support flexible spectral matching, ensuring efficient capture of weak fluorescent signals.
This research achievement is not only a major breakthrough in the study of Vibrio cholerae virulence, but also a strong proof of the capabilities of MSHOT’s inverted fluorescence microscope MF53-N in the field of microbial research.
As a professional microscope manufacturer, MSHOT has always been committed to providing high-quality microscope solutions for scientific research. In addition to the MF53-N, MSHOT boasts a rich product line covering research-grade fluorescence microscopes, high-magnification stereoscopic fluorescence microscopes, live cell scanning analyzers, multi-fluorescence digital slide scanning systems, etc., to meet diverse scientific research needs.